Last edited by Kajir
Saturday, April 18, 2020 | History

2 edition of Sequential medical trials found in the catalog.

Sequential medical trials

P. Armitage

Sequential medical trials

  • 149 Want to read
  • 6 Currently reading

Published by Wiley in New York .
Written in English

    Subjects:
  • Medicine -- Research -- Statistical methods.,
  • Sequential analysis.,
  • Biometry.,
  • Research.

  • Edition Notes

    StatementP. Armitage.
    Classifications
    LC ClassificationsR853.S7 A74 1975
    The Physical Object
    Paginationxi, 194 p. :
    Number of Pages194
    ID Numbers
    Open LibraryOL5184112M
    ISBN 100470033231
    LC Control Number75002211


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Sequential medical trials by P. Armitage Download PDF EPUB FB2

Oct 28,  · Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and Cited by: - Short Book Reviews of the ISI "The statistical methodology for sequential trials is complicated.

This book provides an excellent presentation of it. It succeeds as both a training text and as a reference source. I liked the progression of the bookany statistician involved in designing or analysing sequential trials should have a copy."Cited by: The propriety of such trials is considered.

HIS article has arisen out of an invitation to review the book, Sequential Medical Trials, by Peter Armitage [4]. The reviewer soon found his at- tention focused on certain questions of general statistical principle, that are much "in the air" at the present time.

The book is written from an "orthodox". This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results.

Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries.

These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses.

group sequential methods with applications to clinical trials Download group sequential methods with applications to clinical trials or read online books in PDF, EPUB, Tuebl, and Mobi Format.

Click Download or Read Online button to get group sequential methods with applications to clinical trials book now. This site is like a library, Use. Looking for online definition of sequential trials in the Medical Dictionary.

sequential trials explanation free. What is sequential trials. Meaning of sequential trials medical term. What does sequential trials mean. Sequential trials | definition of sequential trials by Medical dictionary. Note: Citations are based on reference standards. However, formatting rules can vary widely between applications and fields of interest or study.

The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied. By there was already enough accumulated theory and practice to guarantee an audience for the first edition of Armitage's book on Sequential Medical Trials 3.

The principal limitation of the early theory of sequential analysis for implementation in clinical trials was the need to perform an interim analysis after every patient williamblack.club by: 1. Sep 15,  · It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials.

Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important williamblack.club by: Book: Sequential Medical Trials. pp pp.

Abstract: The efficacy of a new prophylactic or therapeutic preparation or procedure can seldom be assessed without recourse to a controlled medical trial During the last 25 years many " treatments " have been submitted to trials conducted under a Author: P.

Armitage. Dec 12,  · Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and Brand: Springer New York.

This is a reply to Professor Anscombe's review article of the author's book, “Sequential Medical Trials.” It is suggested that the use of likelihood inference may have misleading consequences. Anscombe's optimal sequential designs, while giving insight into the problem of designing clinical trials, would be difficult to put into practice Cited by: see more details but by what are called sequential methods.

The inapplicability of standard statistical techniques has, perhaps, in the past discouraged the wider use of sequential medical trials, even where such trials have distinct advantages over fixed-sample-size trials.

The first edition of this book was published in [williamblack.club by: Aug 07,  · Abstract. We discuss issues and methods for the analysis of clinical trials that have formal rules for what is commonly referred to as early williamblack.clubr, we take a broader view, and include trials having a formal sequential stopping rule; the distinction will soon become williamblack.cluber, it is impossible to separate the analysis of such trials from their design, and so we must, of Author: W.

Jackson Hall. Friedman L, Furberg C, DeMets D. Fundamentals of Clinical Trials, 3rd ed. Louis: Mosby-Year Book, Inc., Google ScholarCited by: 2.

Apr 18,  · The medical literature also demonstrates the widening use of sequential methods. Examples of such studies include trials of corticosteroids for AIDS-induced pneumonia, of enoxaparin for prevention of deep vein thrombosis resulting from hip replacement surgery and of implanted defibrilators in coronary heart williamblack.club by: This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results.

Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries/5(2). Sep 28,  · Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics) Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis.

Medical books Group Sequential Methods with Applications to Clinical Trials. At williamblack.club, we keep tabs on overclinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details. Sequential Medicine Ltd (Sponsor) Clinical Trials, 3 Results, Page 1.

3 Clinical Trials Sponsored by Sequential Medicine Ltd. Aberdeen trial of sequential docetaxel after CVAP yielded 31% pCR, 93% survival at 63 months follow up and they concluded that most active drug in CVAP protocol include Adriamycin and cyclophosphamide, combination of AC has been extensively studied hence it would be appropriate to treat LABC with sequential AC-Docetaxel chemotherapy.

A model for sequential clinical trials is discussed. Three proposed stopping rules are studied by the Monte Carlo method for small patient horizons and mathematically for large patient horizons.

Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials.

Special Article Statistics SEQUENTIAL CLINICAL TRIALS IRWIN D. BROSS, Ph.D. NEW YORK, N.Y. From the Cornell University Medical College* (Received for publication June 7, ) I. INTRODUCTION MY purpose here is to discuss a class of techniques called "sequential pro- cedures" which are sometimes useful in clinical williamblack.club by: Mar 21,  · Relatives were recruited in intensive care units after patients had met the criteria for brain stem death.

It is most likely that recruitment of participants was sequential, as it is in most clinical trials. However, the consecutive recruitment of participants is not intrinsic to.

This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs.

Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under. John Whitehead's book on sequential trials is without doubt the standard text in this area, and so a second edition is welcome.

One important change is that there are more examples included of the use of sequential trials in williamblack.club: Gordon D Murray. In statistics, sequential analysis or sequential hypothesis testing is statistical analysis where the sample size is not fixed in advance. Instead data are evaluated as they are collected, and further sampling is stopped in accordance with a pre-defined stopping rule as soon as significant results are observed.

Thus a conclusion may sometimes be reached at a much earlier stage than would be. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text.

williamblack.club: Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics) () by Jennison, Christopher; Turnbull, Bruce W. and a great selection of similar New, Used and Collectible Books available now at great prices.4/5(3).

Journal: Proceedings of the Royal Society of Medicine[/06] Proceedings of the Royal Society of Medicine [01 Jun54(6)].

Read "Group-Sequential Clinical Trials with Multiple Co-Objectives" by Toshimitsu Ochiai available from Rakuten Kobo. This book focuses on group sequential methods for clinical trials with co-primary endpoints based on the decision-making Brand: Springer Japan. Oct 29,  · There are additional online supplements for the book that include chapter-specific exercises and williamblack.clubtial Experimentation in.

IC: I suppose interest in these methods must have been substantial because you prepared a book on Sequential Medical Trials, which was published in (Armitage ).

Did you approach a publisher with a suggestion for the book. PA: After a year in the USA () and talking to people there, I thought there was room for a short book.

Oct 20,  · Download the Medical Book: Group-Sequential Clinical Trials with Multiple Co-Objectives PDF For Free. This Website Provides Free Medical Books. In sequential clinical trials, data from patients treated at the beginning of a trial can be analyzed while the trial is still in progress and subsequent patients can be recruited.

This analysis provides stopping rules whereby the number of patients involved can be limited without affecting the. - Short Book Reviews of the ISI "The statistical methodology for sequential trials is complicated. This book provides an excellent presentation of it.

It succeeds as both a training text and as a reference source. I liked the progression of the book any statistician involved in designing or analysing sequential trials should have a copy.".

Mar 06,  · Most meta-analyses in systematic reviews, including Cochrane ones, do not have sufficient statistical power to detect or refute even large intervention effects.

This is why a meta-analysis ought to be regarded as an interim analysis on its way towards a required information size. The results of the meta-analyses should relate the total number of randomised participants to the estimated Cited by: Dalkvist and Westerlund () used similar assumptions for their simulations and reported corresponding effects--which also brings into focus the fact that their findings are based on a type of dependency that produces much weaker effects than when anticipation increases for sequential trials with the same stimuli (57% versus 69% of the simulations in the direction consistent with.

Sequential AnalysisBIBLIOGRAPHYSequential analysis is the branch of statistics concerned with investigations in which the decision whether or not to stop at any stage depends on the observations previously made.

The motivation for most sequential investigations is that when the ends achieved are measured against the costs incurred (including the cost of making observations), sequential designs. book can be used for short courses on clinical trials, translational medical research, and sequential experimentation.

The authors havesuccessfully used the book to teach innovative clinical trial designs and statistical methods for Statistics Ph. students at Stanford University. Thereare additional online supplements for the book that include. Browse book content. About the book. Search in this book. Search in this book.

Browse content Essential Statistical Methods for Medical Statistics presents only key contributions which have been selected from the volume in the Handbook of Statistics: Medical Statistics, Volume 27 ().

· Clinical trials including sequential and group.Medical Book The Design and Analysis of Sequential Clinical Trials, williamblack.club Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries.

These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses.Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation.

Different parts of the book can be used for short courses on clinical trials, translational medical research, Author: Jay Bartroff.